Glia in health and disease

The Hol lab in the media:

25 May 21.25 hr on NPO1 TV 'Geef om je Hersenen' with an item on our stem cell research. Can the brain repair itself?

Bart Chabot talking to Miriam van Strien



Recent Publications

  • Moeton, Stassen et al. GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions 
    Cell Mol. Life Sci.
  • Hol and Pekny Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system 
    Current Opinion in Cell Biology
  • Osborn, L et al Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease. 
    Prog Neurobiol  
  • Michalidou, I et al Actionvation of endogenous neural stem cells for multiple sclerosis therapy 
    Front Neurosci  
  • Jansen, A.H. et al. The ubiquitin proteasome system in glia and its role in neurodegenerative diseases. 
    Front Mol Neurosci  
  • Kanski, R. et al. Histone acetylation in astrocytes suppresses GFAP and stimulates a re-organization of the intermediate filament network. 
    J Cell Sci
  • Orre, M. et al. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. 
    Neurobiol of Aging



  • 2015 July - Miriam van Strien and Jinte Middeldorp received a ZonMW Memorabel fellowship
  • 2015 Jan - Elly Hol and Erik Boddeke received grant from Memorabel (ZonMW and Hersenstichting Nederland)
  • 2014 June - Jeroen Pasterkamp, Pierre de Graan, and Elly Hol received grant from Dutch Epilepsy Foundation